Abstract
The in vivo metabolism and toxicokinetics of aflatoxin B 1 (AFB 1) were compared among the monkey, rat, and mouse, each representing a different model of sensitivity to the acute and carcinogenic effects of AFB 1. Species relatively sensitive to the acute effect of AFB 1 showed a higher volume of distribution, a higher equilibrium transfer rate constant, higher levels of total aflatoxins in liver and plasma, and a longer plasma biological half-life of AFB 1. Species relatively resistant to the carcinogenic effect of AFB 1 were more active in the in vivo conversion of AFB 1 to aflatoxin P 1 and water-soluble metabolites. In addition, the recovery of aflatoxicol from rat plasma but not from the plasma of similarly treated resistant species, the monkey and mouse, supported and proposed correlation between species sensitivity to the carcinogenic effect of AFB 1 and aflatoxicol-forming activity. The results obtained support previously proposed metabolic models for the prediction of human sensitivity to AFB 1 toxicity.
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