Abstract
Effects of 1α,25(OH) 2–vitamin D 3 and acetylsalicylic acid at various dietary levels of calcium (CaCO 3) on development of aberrant crypt foci (ACF) and tumours in colon were examined in groups of 16 male F344 rats initiated with azoxymethane and observed for 16 weeks. Calcium was the most potent modulator of ACF development. The total number of ACF increased with low calcium and decreased with high calcium. The number of large ACF decreased with any addition of calcium, acetylsalicylic acid and 1α,25(OH) 2–vitamin D 3. High levels of calcium alone or in combination with 1α,25(OH) 2–vitamin D 3 increased the incidence of tumour-bearing animals. 1α,25(OH) 2–vitamin D 3 and acetylsalicylic acid at 5000 ppm calcium increased the incidence as well.
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