Abstract
The Coevolution of IDO1 and AhR in the Emergence of Regulatory T-Cells in Mammals.
Highlights
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the initial rate-limiting step in degrading tryptophan along the kynurenine pathway [5,6,7]
I.e., IDO2 and tryptophan 2,3-dioxigenase (TDO2), catalyze the same reaction along the kynurenine pathway [13], IDO1 is apparently unique in promoting immunoregulatory effects over the long term, owing to its ability to function as a signaling molecule [14,15,16]
IDO1 first appeared in placental animals by duplication of the IDO2 gene [17], suggesting that the coexistence of two allogeneic individuals in the same organism would require advanced strategies of immune regulation capable of maintaining T-cell tolerance for prolonged periods of time
Summary
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the initial rate-limiting step in degrading tryptophan along the kynurenine pathway [5,6,7]. Confined to regulation of tryptophan availability in local tissue microenvironments, IDO1 is considered to play a wider role that extends to homeostasis and plasticity of the immune system.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
