Abstract
On the occasion of the 50th anniversary of the appearance of the first paper on the thermal diffusion column published by Klaus Clusius and Gerhard Dickel a review on the development of this simple tool for the separation of gaseous or liquid mixtures is given. The pioneer work of the inventors is valued and an attempt is made not only to evaluate the development of the thermal diffusion separation process and its impacts to the theory of isotope separation but also to point out the restrictions due to low thermodynamic efficiency.
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