Abstract
Recent publications reporting the generation of human blastocyst-like structures (also known as ‘blastoids’; Liu et al., 2021; Yu et al., 2021) mark an important further step in the modelling of human embryogenesis. This emerging field of research uses advanced (stem) cell technologies and culture systems to enable new insights into early human development and reproductive health. Moreover, it promises to do so in a way that overcomes current limitations on human embryo research. Unlike human embryos, stem cell-based ‘embryo-like structures’ (ELS) – such as ‘blastoids’ or ‘gastruloids’ – can be created and modified ad libitum, enabling studies that require large numbers of genetically identical entities, while bypassing the need for oocyte donation.
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