The clinical value of different GFR methods in renal function evaluation of polycystic kidney diseases

Abstract

Objectives To investigate the application value of 99Tcm-diethylene-triaminepentaacetic acid(99Tcm-DTPA) renal dynamic imaging (method A) and blood creatinine estimation method(method B) in glomerular filtration rate (GFR) detection in different stages of polycystic kidney diseases. Methods A total of 59 polycystic kidney patients without dialysis were divided into the following groups by the gold standard method of double plasma (method C): Group A, GFR≥60 mL/(min·1.73 m2) (including chronic kidney disease(CKD)1-2, 19 cases); Group B, 60 mL/(min·1.73 m2) > GFR ≥30 mL/(min·1.73 m2) (including CKD 3, 23 cases); Group C, GFR < 30 mL/(min·1.73 m2) (including CKD 4-5, 17 cases). The method A GFR and method B GFR were respectively matched with the method C GFR for t-test and Pearson correlation analysis. Results (1) The method B GFR in Group A, B and C were (85.43±19.77), (46.56±15.48), (20.96±11.3) mL/(min·1.73 m2). The method C GFR were (80.58±16.2), (42.66±7.63), (18.61±7.21) mL/(min·1.73 m2) respectively. There was no significant difference between method B and method C in Groups A, B and C(t=-1.462, -1.592, -1.791, all P>0.05). In each group, the method B had a good correlation with method C (r=0.69, 0.68, 0.92, all P 0.05); A significant correlation between method A and method C in both groups was observed (r= 0.55, 0.62, both P 0.05) between method A and method C. Conclusions Gate's method can evaluate renal function in the early stage of polycystic renal disease(CKD 1-3), but the late stage(CKD 4-5) is unsuitable. The blood creatinine estimation method (using the Cockcroft-Gault equation) can evaluate all stages of the renal function of the polycystic kidney disease. Key words: Polycystic kidney diseases; Glomerular filtration rate; Double plasma method; Gate′s method; Blood creatinine estimation method