Abstract
In August 1943 penicillin supplied by the Office of Scientific Research and Development was made available, through the Committee on Chemotherapeutic and Other Agents 1 of the National Research Council, for clinical investigations at Stanford University Hospital. The ensuing report largely concerns our experiences with penicillin, with reference especially to continuous subcutaneous and intravenous infusions, since the subcutaneous and intravenous routes have not been extensively used by most investigators. Penicillin has been furnished to us as the sodium salt. This is a brown or yellow powder, put up in sealed glass ampules, which is extremely soluble in water and in saline or dextrose solution; 10,000 units or more is readily taken up in 1 cc. of fluid. The material is unstable in the air and very hygroscopic; its potency is impaired by heat and in acid mediums. 2 Therefore the sealed ampules must be preserved in the refrigerator until used;
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