The clinical significance of TNFR1 and TNFR2 in early diabetic nephropathy of type 2 diabetes

Abstract

Objective To explore the relationship of serum tumor necrosis factor receptor 1 (TNFR1), and TNFR2 with early diabetic nephropathy in type 2 diabetes patients. Methods A total of 70 patients with type 2 diabetes and 35 healthy person were selected from December 2013 to November 2014 in the Fifth Hospital of Datong, the urinary albumin excretion rate (UAER) was determined, and were divided into three groups: normal control group (n=35), simple diabetes group (n=35), and early diabetic nephropathy group (n=35). Enzyme-linked immuno sorbent assay (ELISA) method was used to determine TNFR1 and TNFR2. Results Compared to normal control group[TNFR1 (302.5±60.0)pg/ml, TNFR2 (62.1±9.8)pg/ml], simple diabetes group[TNFR1 (515.1±78.1)pg/ml, TNFR2 (178.5±38.9)pg/ml], and early diabetic nephropathy group[TNFR1 (1 066.8±205.6)pg/ml, TNFR2 (279.6±37.1)pg/ml]were all increased; and early diabetic nephropathy group was higher than simple diabetes group (P<0.05). The levels of TNFR1 and TNFR2 were positively correlated with age, course, glycated hemoglobin (HbA1c) levels(P<0.01), and were negatively correlated with high density lipoprotein cholesterol (HDL-C) and estimated glomerular filtration rate (eGFR) (P<0.01). The multiple stepwise regression analysis in eGFR had significant effects on TNFR 1 and TNFR 2 levels (P<0.01). Conclusions The levels of TNFR1, and TNFR2 in early diabetic nephropathy were increased. TNFR1 and TNFR2 may become new markers to evaluate early diabetic nephropathy. Key words: Receptors, tumor necrosis factor/ME; Diabetic nephropathies/ME