The clinical observation of different sequences of intravenous administration on sufentanyl-induced cough

Abstract

Objective To evaluate the effects of different sequences of intravenous administration on sufentanyl-induced cough during induction of general anesthesia. Methods One hundred patients,aged 20~60 years,weighing 45~82 kg,ASAⅠorⅡ,scheduled for elective surgery under general anesthesia,were equally randomized to two groups by using a random number table:sufentanyl-propofol group(group SP)and propofol-sufentanyl group(group PS).In group SP,sufentanyl 0.4μg/kg was injected intravenously over 5s,and then propofol 2mg/kg was injected intravenously.In group PS,propofol 2mg/kg was injected intravenously,and then sufentanyl 0.4μg/kg was injected intravenously over 5s.The occurrence,intensity and the time of cough were recorded within 1 min after sufentanyl injection .Results The incidence of cough was 38%(19/50) in group SP which was significantly higher than the 12%(6/50)in group PS(χ2= 9.013,P 0.05). Conclusion Administration in the propofol-sufentanyl sequence can effectively reduce the occurrence of sufentanyl-induced cough as compared with that in the sufentanyl-propofol sequence during induction of general anesthesia. Key words: Sufentanyl; Propofol; Cough