Abstract
S A T U R D A Y 145 Hypersensitivity To Nitrile As A Contact Allergen S. Kumar, J. Moallem, R. Joks; Virginia Commonwealth University, RICHMOND, VA, SUNY Downstate Medical Center, BROOKLYN, NY. RATIONALE: Sensitization and clinical allergy to latex is common. Nitrile products are replacing latex products due to allergic sensitization, especially in hospitals. Clinical allergy to nitrile products is not recognized among health care workers and others routinely exposed to nitrile. We devised a modified skin prick test methodology to test for nitrile hypersensitivity. METHOD: Adults (n5 3), either health care workers or dialysis patients, with a history of cutaneous hypersensitivity reaction to nitrile glove underwent a modified skin prick challenge through nitrile glove material to assess immediate hypersensitivity, as well as Finn chamber patch testing for delayed hypersensitivity. RESULTS:All patients in the studywith history consistent with type-1 hypersensitivity reaction to nitrile glove tested positive with a wheal and flare reaction similar to histamine control; none had positive patch test reactivity. CONCLUSIONS: Nitrile contact allergy is an unrecognized problem in health care. This modified skin test methodology is a new tool in the diagnosis of nitrile allergy.
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