Abstract
随着人们对肺癌早期筛查的重视，肺多发磨玻璃影（multiple ground glass opacities, GGOs）的检出率逐年增高，以GGOs为表现的多灶肺腺癌也逐渐成为临床研究热点。其更多见于女性、非吸烟者，且无论是自然病程还是手术后的患者均有极佳预后。独特的临床特征提示其很可能是相对独立的一种疾病形式。从分子遗传学路径对其的探究发现，同一个体内的多个病灶间极可能有截然不同的克隆性特征，因此遗传异质性（genetic heterogeneity）是以GGOs为表现多灶肺腺癌最显著的分子遗传学特征。此特征可辅助原发多灶肺腺癌与肺癌肺内转移的鉴别诊断，也提示了对病灶进行分子遗传学检测的治疗意义。部分呈现出遗传相似性的GGOs病灶为气腔播散转移（spread through air spaces, STAS）理论提供了新的证据。
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