Abstract
This chapter discusses the clear cell system of the peripheral endocrine glands. This clear cell system is found at the entodermal locations, for example, nasal mucous; membrane; salivary glands; gastric mucous membrane; intestinal mucous membrane; gall-bladder mucous membrane; bronchial mucous membrane; and urinary bladder epithelium. In addition to the clearness of their cytoplasm, argyrophil and argentaffin granulations as well as a positive diazonium reaction constitute the remarkable histological qualities of the clear cells. They do not always completely manifest these qualities at the locations cited. It is required to differentiate between man and animal, child and adult and normal, and pathological conditions. The hypothesis of the peripheral entodermal endocrine glands is confirmed by the evidence of a pressor agent in the enteral carcinoid, by the discovery of the islet cells of the pancreatic duct with A and B cells. Also found is argyrophil clear cells in entodermal central endocrine glands: thyroid, and parathyroid. Argyrophil and argentaffin carcinoids in cystic teratomas of the mesodermal female and male gonads are derived from the argyrophil and argentaffin cells of rudimentary intestinal and bronchial formations in the teratomas.
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