Abstract
Ceruletide, a non-mammalian decapeptide related to cholecystokinin octapeptide, reduced the aggressiveness of isolated NMRI mice. In this respect, its ED 50, (μmol/kg, s.c.) was 0.024 (95% confidence range, 0.0133–0.0447) and that of haloperidol 3.38 (1.488–7.669). An approximately equipotent dose of diazepam was 17.5 μmol/kg.
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