Abstract
To evaluate the morphological characteristics of flow void (FV) in the fellow eyes of the unilateral polypoidal choroidal vasculopathy (PCV). Fifty PCV fellow eyes (PCVF) and 31 age-matched normal ocular circulation controls were recruited in this retrospective study. The number of FV was analyzed according to the size in a centered 5 × 5 mm swept source optical coherence tomography angiography scans. We used indocyanine green angiography images to determine whether choroidal vascular hyperpermeability (CVH) has occurred. For the PCVF, the prevalence rate of CVH was 70% (35 of 50) The number of FVs was significantly lower in 400–25,000 μm2 (P = 0.005), 400–500 μm2 (P = 0.001), 525–625 μm2 (P = 0.001) and 650–750 μm2 (P = 0.018). compared to the controls. And showed no difference in size from 775 to 1125 μm2 between the two groups. The area under the receiver operating characteristic curve of PCVF with CVH and controls was 0.94 (95% CI 0.88–1.00) (P < 0.001). We found that the number of small FVs was significantly lower in the PCV fellow eyes than that in the eyes with control group.
Highlights
To evaluate the morphological characteristics of flow void (FV) in the fellow eyes of the unilateral polypoidal choroidal vasculopathy (PCV)
We used CC flow void (FV) as a substitution for the CC structure, which was defined as the part of the CC slab without blood flow signals that diameter was bigger than the resolution of the SS-optical coherence tomography angiography (OCTA) instrument
The number of FVs smaller than 750 μm[2] substantially decreased in the PCV fellow eyes (PCVF) group compared to the control group; whereas, the total FV area did not differ between the two groups
Summary
To evaluate the morphological characteristics of flow void (FV) in the fellow eyes of the unilateral polypoidal choroidal vasculopathy (PCV). The changes of the choriocapillaris (CC) in PCV would be expected It has been r eported[4] that there was no difference in vascular parameters of the choroidal vasculature, including the CC between the pachychoroid eyes without disease and normal eyes in a study using optical coherence tomography angiography (OCTA). Other studies[5] have found that the CC flow deficit of PCV fellow eyes decreased, but did not reach statistical difference compared to the age-matched control group. Swept-source optical coherence tomography angiography (SS-OCTA) is often used to evaluate CC 2D images, due to its high scanning speed for evaluation It has a wide depth range, the lateral resolution is generally lower than the spectral-domain OCTA. We used CC flow void (FV) as a substitution for the CC structure, which was defined as the part of the CC slab without blood flow signals that diameter was bigger than the resolution of the SS-OCTA instrument
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