Abstract
Klebsiella pneumoniae is an important gram-negative opportunistic pathogen that causes a variety of infectious diseases, including urinary tract infections, bacteremia, pneumonia, and liver abscesses. With the emergence of multidrug-resistant (MDR) and hypervirulent K. pneumoniae (hvKP) strains, the rapid spread of these clinical strains in geography is particularly worrying. However, the detailed mechanisms of virulence and antibiotic resistance in K. pneumoniae are still not very clear. Therefore, studying and elucidating the pathogenic mechanisms and drug resistance mechanism of K. pneumoniae infection are important parts of current medical research. In this paper, we systematically summarized the virulence, biofilm, and antibiotic tolerance mechanisms of K. pneumoniae, and explored the application of whole genome sequencing and global proteomics, which will provide new clues for clinical treatment of K. pneumoniae.
Highlights
Klebsiella pneumoniae is a class of gram-negative bacterium that is ubiquitously found on the surface of mucosa in animals, or in the environment
In China, K. pneumoniae accounted for 11.9% of isolated pathogens from ventilator-associated pneumonia (VAP) and intensive care unit (ICU)-acquired pneumonia [4]
Hsieh et al reported that YfgL (BamB) lipoprotein is involved in the biofilm formation of K. pneumoniae and the transcriptional expression of type 1 pili, which is critical for the anti-phagocytosis of K. pneumoniae in vivo [25]
Summary
Klebsiella pneumoniae is a class of gram-negative bacterium that is ubiquitously found on the surface of mucosa in animals, or in the environment (such as water, soil, etc.). In the era of antibiotics that followed, it became a major cause of medical-related infections in hospitals [1], and a risk factor of severe community-acquired infections [2]. There is no doubt that such a high prevalence and mortality rate of K. pneumoniae infection caused a great burden on the country’s health system. According to the accessory genome, K. pneumoniae strains are divided into three types: opportunistic, hypervirulent, and multidrug-resistant (MDR) [6]. The characteristic of MDR K. pneumoniae is closely related to the antibiotic resistance genes (ARGs) encoded by plasmid. Benefitting from plasmids and transferable genetic elements, K. pneumoniae continues to accumulate ARGs in the context of improper antibiotic use, resulting in the emergence of an extremely drug-resistant (XDR) strain with “super resistome” [10]. Further exploration of mechanisms of virulence and drug resistance in K. pneumoniae are urgently needed
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Environmental Research and Public Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
