Abstract
Phenolic compounds and thiamine may serve as therapies against oxidative stress-related neurodegenerative diseases. However, it is important to note that these components show high instability under changing conditions. The study’s aim was to determine the impact of the thiamine concentration (hydrochloride—TH and pyrophosphate—TP; in the range 0.02 to 20 mg/100 g on the indices of the chelating properties and reducing power, and free radicals scavenging indices of EGCG, EGC, ECG and caffeine added from 0.04 to 6.0 mg/100 g. Our research confirmed that higher concentrations of TH and TP can exhibit significant activity against the test antioxidant indices of all components. When above 5.0 mg/100 g of thiamine was used, the radical scavenging abilities of the compound decreased in the following order: EGCG > ECG > EGC > caffeine. The highest correlation was found for the concentration of thiamine pyrophosphate to 20.0 mg/100 g and EGCG. Knowledge of the impact of factors associated with the concentration of both EGCG, EGC, ECG or caffeine and thiamine on their activity could carry weight in regulating the quality supplemented foods, especially of nutrition support for people of all ages were oral, enteral tube feeding and parenteral nutrition).
Highlights
IntroductionGiovanna Giovinazzo and Thiamine must be regularly supplied to the human body in adequate amounts with food, in which it occurs both in free form and as mono-, pyro- and triphosphate esters.Currently, in highly developed societies, the risk group for thiamine deficiency includes, for example, diabetics, patients after extensive surgeries, pregnant and lactating women, smokers, alcoholics, as well as people with obesity and preferring high-carbohydrate diets [1,2,3,4,5,6]
Giovanna Giovinazzo and Thiamine must be regularly supplied to the human body in adequate amounts with food, in which it occurs both in free form and as mono, pyro- and triphosphate esters.Currently, in highly developed societies, the risk group for thiamine deficiency includes, for example, diabetics, patients after extensive surgeries, pregnant and lactating women, smokers, alcoholics, as well as people with obesity and preferring high-carbohydrate diets [1,2,3,4,5,6]
It was found that the samples with epigallocatechin gallate (EGCG) exhibited the highest antioxidant activity most often, whereas the lowest activity was observed in the samples with caffeine
Summary
Giovanna Giovinazzo and Thiamine must be regularly supplied to the human body in adequate amounts with food, in which it occurs both in free form and as mono-, pyro- and triphosphate esters.Currently, in highly developed societies, the risk group for thiamine deficiency includes, for example, diabetics, patients after extensive surgeries, pregnant and lactating women, smokers, alcoholics, as well as people with obesity and preferring high-carbohydrate diets [1,2,3,4,5,6]. Attention should be paid to studies related to the observations of thiamine deficiency in HIV-infected individuals [7,8] and with gastroenterological cancer [4]. Thiamine deficiency is very common in patients with severe kidney disease who undergo regular dialysis [9,10], which impairs nerve conduction, causing neuropathies, among other issues. Thiamine deficiency is a very difficult problem in geriatrics. In patients with thiamine deficiency, cases of Alzheimer’s disease, depression and heart failure were reported more frequently [12,13,14,15]. The demonstrated thiamine deficiency was associated with the deterioration of the rate of thiamine absorption in the digestive system with the patient’s age (hospitalizations) [16,17]
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