Abstract
ABSTRACTBackground:It is believed that the Wnt pathway is one of the most important signaling involved in gastric carcinogenesis. Aim:To analyze the protein expression of canonical and non-canonical Wnt pathways in gastric carcinoma. Method:The immunohistochemistry was performed in 72 specimens of gastric carcinomas for evaluating the expression of Wnt-5a, FZD5, GSK3β, axin, CK1, ubiquitin, cyclin D1 and c-myc. Results:There were significant differences for cytoplasm and nucleus ubiquitin for moderately and well differentiated tumors (p=0.03) and for those of the intestinal type of the Lauren classification (p=0.03). The absence of c-myc was related to Lauren’s intestinal tumors (p=0.03). Expression of CK1 in the cytoplasm was related to compromised margin (p=0.03). Expression of cyclin D1 protein was more intense in male patients (p=0.03) There was no relation of the positive or negative expression of the Wnt-5a, FZD5, GSK3 and Axin with any clinicopathological variables. Conclusion: The canonical WNT pathway is involved in gastric carcinoma.
Highlights
Gastric carcinoma has high global incidence and low average survival in both developed and developing countries
In order to identify another Wnt pathway proteins in these same samples we propose the study of two non-canonical pathway proteins (Wnt-5a, FZD5) and six canonical pathways proteins (GSK3B, axin, CK1, ubiquitin, cyclin D1 and MYC) and relate their expression with epidemiological and anatomopathological characteristics of the tumor
The results suggested that Wnt-5a protein is involved in the progression of gastric cancer, a finding similar to that of other authors[15,29,33]
Summary
Gastric carcinoma has high global incidence and low average survival in both developed and developing countries. Signaling is initiated when ligands of Wnt pathway are attached in a complex consisting of a receptor of frizzled family and a member of the family of low density lipid receptors[24]. Wnt proteins play an important role in embryogenesis and maturation of tissues. These proteins act as ligands to components of frizzled family that are transmembrane cellular receptors. Once attached to these receptors, Wnt proteins can activate two distinct pathways of cell signaling: canonical and non-canonical pathways. The Wnt signaling pathway is involved in gastric carcinogenesis and several proteins of this pathway may be mutated or expressed atypically in gastric tumor tissue
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