Abstract
The bronchodilator activity of 20-isopropylidene prostaglandin E 2 (CS-412) was studied in vivo . In the conscious guinea pig, aerosols of CS-412, prostaglandin E 2 (PGE 2), or salbutamol afforded similar protection against histamine-induced convulsions. In the anesthetized guinea pig, where increase in intratracheal pressure was taken as an index of bronchoconstriction, CS-412, PGE 2, and salbutamol were equipotent in inhibiting the bronchoconstriction induced by histamine. CS-412, PGE 2 and salbutamol were equally effective in reducing the serotonin-induced increase in pulmonary resistance in the anesthetized cat. CS-412 was different from PGE 2 in bronchoconstrictor activity in anesthetized cats with normal bronchotonus. PGE 2 caused bronchoconstriction in the cats. CS-412 showed 30 times less constrictor activity than PGE 2. It was concluded that CS-412 is an effective bronchodilator without unfavorable side effects.
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