Abstract
The central nervous system (CNS) has been considered to be an immunologically privileged site (1). This is partly due to the paucity of professional antigen presenting cells within the CNS and the lack of lymphatic drainage (2). In addition, there is very little expression of major histocompatibility antigens (MHC) within the CNS. Finally, the blood-brain barrier (BBB) normally protects the CNS from immunological damage. The BBB is formed by astrocytes and specialized cerebrovascular endothelial cells (CVE) which line the lumen of the blood vessels (3). The endothelial cells have relatively few pinocytic vesicles and no constitutive MHC Class II expression unlike endothelial cells that supply other organs (4).KeywordsDemyelinating DiseaseViral ClearanceMouse Hepatitis VirusPersistent Viral InfectionDemyelinating ProcessThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
