Abstract
The whole of the complex field of microtubule structure and function is far too broad to cover in this brief review. The intention has been to give a brief overview of the field and to place emphasis on a few areas of recent significant progress. In particular, the related topics of microtubule “treadmilling,” polarity of assembly, and role of nucleotide hydrolysis have been addressed at some length, as has the topic of tubulin heterogeneity. For a more detailed discussion, several recent books can be recommended. Microtubules (Roberts and Hyams, eds., 1979) contains excellent reviews on the major areas of microtubule structure, chemistry, mechanisms of assembly, and functions. Microtubules and Microtubule Inhibitors (De Brabander and De Mey, eds., 1980) contains briefer articles on many topics of current interest. In Microtubules (1978), P. Dustin has authored a remarkably comprehensive review which is especially strong in providing historical perspective, to which this present review is heavily indebted. Also to be recommended is the more recent book Biological Functions of Microtubules and Related Structures (Sakai et al.,1982).
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