Abstract
Background The purpose of this study was to examine the benefits of inositol-stabilized arginine silicate (ASI; Nitrosigine) as a workout ingredient in healthy adults. ASI has been previously shown to significantly enhance blood levels of arginine up to six hours post-dose and increase nitric oxide levels. To investigate reports of enhanced energy, increased muscle pump and stamina during workouts, and faster muscle recovery post-workout, ASI (1,500mg/ day) was tested in a double-blind placebo-controlled crossover-design (DBPC-X) study using the POMS vigor-activity and fatigue-inertia sub-scores, blood flow measurements, leg circumference measurements, and biomarkers of muscle recovery (creatine kinase (CK) and lactate dehydrogenase (LDH)) as outcome measures.
Highlights
The purpose of this study was to examine the benefits of inositol-stabilized arginine silicate (ASI; Nitrosigine®) as a workout ingredient in healthy adults
CK levels significantly decreased in the ASI group at 24 (p = 0.040), 48 (p = 0.017) and 72 (p = 0.034) hours postexercise compared to the placebo group
LDH levels significantly increased from baseline immediately after exercise in the placebo group (p = 0.015), but not in the ASI group (p = 0.366); p = 0.133 between groups
Summary
The purpose of this study was to examine the benefits of inositol-stabilized arginine silicate (ASI; Nitrosigine®) as a workout ingredient in healthy adults. ASI has been previously shown to significantly enhance blood levels of arginine up to six hours post-dose and increase nitric oxide levels. To investigate reports of enhanced energy, increased muscle pump and stamina during workouts, and faster muscle recovery post-workout, ASI (1,500mg/ day) was tested in a double-blind placebo-controlled crossover-design (DBPC-X) study using the POMS vigor-activity and fatigue-inertia sub-scores, blood flow measurements, leg circumference measurements, and biomarkers of muscle recovery (creatine kinase (CK) and lactate dehydrogenase (LDH)) as outcome measures
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