Abstract
Neutral 99 m Tc-chelates were formed with propylene amine oxime, 3,3′-(1,3-propanediyldiimino)bis-(3-methyl-2-butanone)-dioxime and other PnAO analogues. Even though the other amine oxime ligands form neutral chelates with 99 m Tc, the stability, lipophilic and the brain uptake characteristics are less desirable than [ 99 m Tc]-PnAO. These results demonstrate that slight modifications in the amine oxime ligand backbone produces significant effects on the chemical and biological behavior of the [ 99 m dioxime chelates.
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