Abstract
BackgroundGlaucoma is a complex multivariate disorder characterized by retinal ganglion cell (RGC) loss and optic nerve degeneration. Evidence suggests the role of estradiol (E2) and the etiology of glaucoma. Therefore, this present study evaluates the association between estrogen-signaling pathways and the risk of open-angle glaucoma (OAG).ResultsMeta-analysis was performed from available studies that investigated intraocular pressure (IOP) in patients treated with or without hormone replacement therapy (HRT) and studies that evaluated the associations between estrogen receptor (ER) polymorphisms and the risk of OAG. The pooled result showed that HRT had a positive effect in lowering IOP. Moreover, ERβ polymorphisms showed a significant association with the risk of OAG.ConclusionThis report supports the notion that estrogen-signaling pathways play a pivotal role in the development of OAG.
Highlights
Glaucoma is a complex multivariate disorder characterized by retinal ganglion cell (RGC) loss and optic nerve degeneration
2.1 Effect of hormone replacement therapy (HRT) in lowering intraocular pressure (IOP) To evaluate the efficacy of HRT in lowering IOP, the selection criteria were as follows: (1) comparing the IOP of HRT-treated patients with controls, (2) patients were female in a menopausal period, (3) a case-control design, and (4) pre-post treatment evaluation
10 studies included in this meta-analysis measured the IOP from menopausal women with or without HRT (Table 1)
Summary
Glaucoma is a complex multivariate disorder characterized by retinal ganglion cell (RGC) loss and optic nerve degeneration. Evidence suggests the role of estradiol (E2) and the etiology of glaucoma. This present study evaluates the association between estrogen-signaling pathways and the risk of open-angle glaucoma (OAG). Glaucoma is a complex multivariate disease characterized by retinal ganglion cell (RGC) loss and optic nerve degeneration [1]. It is well known that open-angle glaucoma (OAG) is the most common type of glaucoma [3]. Several risk factors have been identified and associated with the etiology of glaucoma including elevation of IOP, immune and inflammatory mediators, and oxidative stress [4]. The prevalence of OAG is likely observed in men and linearly increases with age [6], suggesting that female sex steroid hormones contribute to the development of OAG
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Beni-Suef University Journal of Basic and Applied Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
