Abstract
phenone). Linear regression models with fixed and random effects were used to estimate beta coefficients (b) and standard errors (SE) for each UV filter and Box-Cox transformed semen quality endpoint, after adjusting for age, body mass index, cotinine, and research site. RESULTS: 413 (88%) men provided urine and R1 semen samples available for analysis. Four UV filters were significantly associated with R1 semen parameters; 3 were negatively associated with percent motility (BP1, BP-3, 4-OH-BP). BP-8 was associated with both high DNA stainability (b -0.80 SE 0.23, p0.004) and DNA fragmentation (b 1.04 SE0.52, p0.04). CONCLUSION: Our findings provide the first evidence suggesting that UV filters may affect semen quality, but corroboration of findings is needed given our exploratory analysis. Supported by: NICHD Intramural funding (contracts #N01-HD-3-3355; N01-HD-3-3356; NOH-HD-3-3358; HHSN27500001).
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