Abstract
Objective To explore the association of 433E1006 and rs3924999 locate in the neuregulin 1 (NRG1) gene polymorphism with schizophrenia. Methods Included and selected the published data related to the single marker 433E1006(G/A) and rs3924999(A/G)of NRG1 in the database of pubmed, metstr, EMBASE, Wanfang, and CNKI. Meta-analysis was used to analyze the data by using software Revman 5.0. Results 5 case-control studies(2 501 cases and 2 283 healthy controls) related to 433E1006 and 9 case-control studies(3 256 cases and 4 143 healthy controls) related to rs3924999 met with the inclusion criteria contributed to the according meta-analysis.There was no significant difference of distribution of allelic G from433E1006 and G from rs3924999 between case and control group(P>0.05). The odds ratio(OR) of G allelic of 433E1006 and rs3924999 was 1.14, 1.04, the 95% confidence interval was 0.95-1.37 and 0.91-1.19, the Z value was 1.45 and 0.62, and P value was 0.15 and 0.54, respectively. Conclusions There is no evidence to support the association of 433E1006 and rs3924999 locate in NRG1 gene with schizophrenia. Key words: Schizophrenia; Neuregulin1 gene; Single nucleotide polymorphism(SNP); Association analysis; Meta-analysis
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