Abstract
Objective: The aim of the present study is to investigate the association between the single nucleotide polymorphism (SNP) sites of peroxisome proliferator-activated receptor Δ (PPARD) and the risk of coronary artery disease (CAD). To this end, a prospective observational single-center study of the clinical data from 880 subjects in a Chinese population was conducted. Methods: A total of 880 subjects, including 609 CAD patients and 271 control subjects, were selected for the present study. All inpatients had 4 ml of venous blood drawn after 12 h of fasting, and then clinical tests were conducted to obtain the biochemical parameters. CAD patients and Controls were distinguished by coronary angiography. Statistical analysis was conducted with SPSS software (ver 16.0). Results: A significant association between the G-alleles of PPARD rs3777744 and rs3798343 and a decreased risk for CAD was found. Moreover, we found an interaction between high fasting high-density lipoprotein cholesterol (HDL-C) serum levels, low serum glucose levels and their genotypes, ultimately decreasing the risk of CAD. Haplotype analysis was conducted on the three SNP sites, rs3777744 and rs3798343 to form a block [r2 = 0.79, D′ = 0.99). The A-C haplotypes were associated with an increased risk of CAD (odds ratio (OR), 95% confidence interval (CI): 1.321 (1.060–1.647), P=0.013], and the G-G haplotypes were associated with a decreased risk [OR, 95% CI: 0.714 (0.567–0.849), P=0.004]. Conclusions: Our study indicates a significant association between the G-alleles of PPARD rs3777744 and rs3798343 and a decreased CAD risk. In addition, genotypes interact with high serum HDL-C levels and low serum glucose levels, resulting in decreased prevalence of CAD.
Highlights
Cardiovascular diseases (CVD), coronary artery disease (CAD), are typically caused by atherosclerosis (AS) and are a major cause of deaths worldwide [1]
The aim of the present study is to investigate the association between the single nucleotide polymorphism (SNP) sites of peroxisome proliferator-activated receptor (PPARD) and the risk of coronary artery disease (CAD)
Serum levels of total cholesterol (TC), TG, fasting low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (Apo-A), apolipoprotein B (Apo-B), and drinking status were comparable between the CAD and control groups
Summary
Cardiovascular diseases (CVD), coronary artery disease (CAD), are typically caused by atherosclerosis (AS) and are a major cause of deaths worldwide [1]. CAD is mainly diagnosed by angiography, an invasive examination that can be harmful to patients [2]. Despite great developments in the diagnosis and treatment of CAD, early diagnosis remains a challenge in clinical practice. Specific and sensitive biomarkers for inchoate detection of CAD are necessary. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors, including PPAR α (PPARA), PPAR (PPARD), and PPAR γ (PPARG) [3]. PPARs are highly c 2019 The Author(s).
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