Abstract
BackgroundHigh-sensitivity C-reactive protein (hs-CRP) is a common risk factor for developing cardiovascular disease. However, there has been no study reporting the relationship between hs-CRP and blood pressure in Yi adults. The aim of this study is to investigate the association between hs-CRP and blood pressure in Yi adults.MethodsIn this cross-sectional study, included subjects were 2916 Yi migrants or farmers aged 20–80 years, recruited by using a stratified cluster sampling method from Liangshan Yi Autonomous Prefecture of Sichuan Province in 2014. The directed acyclic graphs(DAG) was used to select a minimal sufficient adjustment sets of variables which would identification the unconfounded effect of hs-CRP and hypertension. Multiple linear and multinomial logit analysis were used to estimate the effect of hs-CRP on SBP/DBP/MAP/PP and the prevalence of prehypertension/hypertension after adjustment for the relevant confounders.ResultsThe median level of hs-CRP was 1.20 (0.50–3.06)mg/L in Yi migrants, and 0.84(0.36–2.52) mg/L in Yi farmers, and the prevalence of high hs-CRP was 23.25%. For hs-CRP > 3 mg/L group, the adjusted PP tended to have lower values (β = − 1.49, 95%CI: − 2.49--0.49, P = 0.0034) compared with < 1 mg/L group. After adjusting for confounders, there were no significant association between hs-CRP and prehypertension/hypertension (P > 0.05).ConclusionsOur results suggest that high hs-CRP is prevalent in Yi people, and this study does not support hs-CRP as a risk factor of prehypertension or hypertension.
Highlights
High-sensitivity C-reactive protein is a common risk factor for developing cardiovascular disease
Protein was initially produced in hepatocytes stimulated by interleukin-6 (IL-6) and Tumor Necrosis Factor (TNF), which were the biomarkers of systemic inflammation [7]
Multiple linear and multinomial logit analysis were used to estimate the effect of High-sensitivity C-reactive protein (hs-CRP) on Systolic Blood Pressure (SBP)/Diastolic Blood Pressure (DBP)/Mean Arterial Pressure (MAP)/ Pulse Pressure (PP) and the prevalence of prehypertension/hypertension after adjustment for gender, age, Yi farmers or Yi migrants, education, history of hypertension, smoking, overweight/obesity and dyslipidemia
Summary
High-sensitivity C-reactive protein (hs-CRP) is a common risk factor for developing cardiovascular disease. There has been no study reporting the relationship between hs-CRP and blood pressure in Yi adults. The aim of this study is to investigate the association between hs-CRP and blood pressure in Yi adults. As a primary risk factor of cardiovascular disease [1], hypertension has affected 23.2% of the Chinese adult population (approximately 244.5 million) with the age ≥ 18 years old [2]. Hs-CRP was demonstrated to serve as an indicator to identify the risk of cardiovascular events in patients with high blood pressure [8,9,10]. A meta-analysis of cohort studies revealed that high levels of hs-CRP was associated with the risk of hypertension development [11]. A variety of studies have indicated the inhomogeneity of the levels of hs-CRP among different ethnicities or races [12,13,14]
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