Abstract
ObjectiveTo evaluate the association between endometriosis and chronic endometritis.MethodsEndometrial specimens were obtained from 71 patients, 34 with endometriosis (endometriosis group) and 37 without endometriosis (non-endometriosis group), who underwent hysterectomy, and the specimens were immunostained for the plasmacyte marker CD138. The rate of chronic endometritis was compared between the endometriosis group and the non-endometriosis group. Furthermore, the 71 patients were also divided into two groups, 28 with chronic endometritis (chronic endometritis group) and 43 without chronic endometritis (non-chronic endometritis group). Logistic regression analysis was performed with variables including age, body mass index (BMI), gravidity and parity, and diagnoses of leiomyoma, adenomyosis, and endometriosis on pathology to examine the independent effect of each variable on chronic endometritis. Patients suffering from cervical invasive carcinoma, endometrial carcinoma, and endometrial polyps or treated with gonadotropin-releasing hormone agonists, progestins, or oral contraceptives before surgery were excluded.ResultsChronic endometritis was identified in 52.94% of the endometriosis group and 27.02% of the non-endometriosis group (p<0.05). Logistic regression analysis revealed that endometriosis was associated with chronic endometritis.ConclusionsThis result suggests a strong association between endometriosis and chronic endometritis.
Highlights
Chronic endometritis is a persistent inflammation of uterine endometrium, and it is diagnosed histopathologically as plasmacyte infiltration within the endometrial stromal compartment [1,2]
Recent studies have reported that chronic endometritis is associated with infertility and recurrent abortion; it has been identified in 12–46% of infertile patients, 30% of repeated implantation failures after in vitro fertilization-embryo transfer, 28% of unexplained infertility, and 12% of unexplained recurrent miscarriages [3,4,5,6,7]
The present results demonstrated an association between endometriosis and chronic endometritis
Summary
Chronic endometritis is a persistent inflammation of uterine endometrium, and it is diagnosed histopathologically as plasmacyte infiltration within the endometrial stromal compartment [1,2]. It is usually asymptomatic or presents only with subtle symptoms such as abnormal uterine bleeding, pelvic pain, dyspareunia, and leucorrhea. A number of immune cells including plasma cells is found in the endometrium. Given the presence of abnormal immune cells in the endometrium, chronic endometritis may affect the development and maintenance of other reproductive diseases
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