Abstract
Hypoxic cells are radiation-resistant relative to oxic cells and it is now well established, both in experimental murine tumour systems, and in some clinical situations, that this resistance can adversely influence local tumour control by radiation. There is also evidence to suggest that oxygen-deficient tumour cells can be refractory to some anti-cancer agents1 – 3. Hypoxic cells are likely to be quiescent thereby limiting their sensitivity to cycle-selective agents and, because of their location, poorly accessible to cytotoxic drugs. Hypoxia will also affect the activity of a drug if oxygen- dependent processes are required for its cytotoxic effect. Further, it has been shown that hypoxia can induce gene amplification resulting in drug resistance4.
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