Abstract
Olea europaea leaves are one of the most widely used by-products in traditional medicine due to their biological properties. This study evaluated the antioxidant activities, and the beneficial effects of the aqueous extract of “Sahli” Olea europaea leaves on diclofenac-induced haematotoxicity and nephrotoxicity in Swiss albino mice. The mice were divided into four groups of seven each: a control group, a diclofenac-treated group, a group orally gavaged with the extract of olive leaves, and a group pre-treated with the extract of olive leaves and then injected with diclofenac. The results obtained indicated that the injection of the mice with diclofenac alone caused an extensive change in their haematological and biochemical parameters, such as red and white blood cells (RBC and WBC, respectively), platelet count (PLT), and creatinine and urea levels, a significant increase in lipid peroxidation level (TBARS) and a decrease in superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) levels. Olive leaf extract administration in the diclofenac-treated mice was found to correct and restore all the investigated parameters and protect the kidney histology by minimizing the oxidative stress induced by diclofenac in the mice tissues.
Highlights
Non-steroidal anti-in ammatory drugs (NSAID) are a diverse group of chemical agents[1] with similar biological capabilities, regularly used for pain relief and the treatment of many in ammatory diseases.[2]
DF, a non-steroidal anti-in ammatory drug (NSAID) that belongs to the acetic acid group, was purchased from the Central Pharmacy of Gafsa Tunisia, which was produced by the “DAR ESSAYDALI LABORATORY” Tunisia to be dissolved in saline solution for injection
Exposure of the mice to DF for ve consecutive days caused a signi cant reduction in red blood cells (RBC), white blood cells (WBC), haemoglobin (Hg), haematocrit (Ht), mean corpuscular volume (VCM) and mean cell haemoglobin concentration (MCHC) values (5.03 Æ 0.78 Â 106/mL, 5.71 Æ 1.50 Â 103/mL, 9.73 Æ 0.82 g dLÀ1, 30.66 Æ 2.1%, 36.3 Æ 7.4 10À6 mm[3] per Red blood cells (RBC), 28.10 Æ 0.84 g dLÀ1, respectively), while a signi cant increase in platelet number (887.33 Æ 7.73 Â 103 mL) as compared to the control group (C) was observed (Table 1)
Summary
Non-steroidal anti-in ammatory drugs (NSAID) are a diverse group of chemical agents[1] with similar biological capabilities, regularly used for pain relief and the treatment of many in ammatory diseases.[2] Diclofenac (DF) belongs to the family of NSAID, which is considered as one of the most commonly used painkillers.[3]. E-mail: raouiya_soussi@yahoo. fr; Tel: +21622507475 bResearch Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, University of Gafsa, Gafsa, 2112, Tunisia compared to synthetic drugs,[9] which are regarded as unsafe to humans and the environment.[9]
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