Abstract
Chemiluminescence technique as a novel detection method has gained much attention in recent years owning to the merits of high sensitivity, wider linear ranges, and low background signal. Similarly, nanotechnology especially for gold nanoparticles has emerged as detection tools due to their unique physical and chemical properties. Recently, it has become increasingly popular to couple gold nanoparticles with chemiluminescence technique in biological agents’ detection. In this review, we describe the superiority of both chemiluminescence and gold nanoparticles and conclude the different applications of gold nanoparticle-initialed chemiluminescence in biomedical detection.
Highlights
Detection of biological agents plays an indispensable role in biomedicine [1]
In clinical diagnosis, developing highly sensitive and cost-effective detection methods is in high demand for the reason that some clinical samples have very low concentration that usually cannot be detected
The Strategies of CL Based on Labeling AuNPs The CL detection methods based on AuNPs have two approaches: (i) AuNPs are directly used as catalyst to amplify CL signal. (ii) The detection signal is amplified by the biomolecules loading on the surface of AuNPs such as antibody, horseradish peroxidase (HRP), luminol, and biotin
Summary
In clinical diagnosis, developing highly sensitive and cost-effective detection methods is in high demand for the reason that some clinical samples have very low concentration that usually cannot be detected. The Strategies of CL Based on Labeling AuNPs The CL detection methods based on AuNPs have two approaches: (i) AuNPs are directly used as catalyst to amplify CL signal. (ii) The detection signal is amplified by the biomolecules loading on the surface of AuNPs such as antibody, horseradish peroxidase (HRP), luminol, and biotin.
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