Abstract
BackgroundVisceral adiposity index (VAI), a novel sex-specific index for visceral fat measurement, has been proposed recently. We evaluate the efficacy of VAI in identifying diabetes risk in Chinese people, and compare the predictive ability between VAI and other body fatness indices, i.e., waist circumference (WC), body mass index (BMI) and waist- to- height ratio (WHtR).MethodsParticipants (n = 3,461) were recruited from an ongoing cohort study in Jiangsu Province, China. Hazard ratio (HR) and corresponding 95% confidence interval (CI) between diabetes risk and different body fatness indices were evaluated by Cox proportional hazard regression model. Receiver operating characteristic (ROC) curve and area under curve (AUC) were applied to compare the ability of identifying diabetes risk between VAI, WC, WHtR and BMI.ResultsA total number of 160 new diabetic cases occurred during the follow-up, with an incidence of 4.6%. Significant positive associations were observed for VAI with blood pressure, fasting plasma glucose, triglyceride, WC, BMI and WHtR. Moreover, increased VAI was observed to be associated with higher diabetes risk with a positive dose–response trend (p for trend < 0.001). As compared to individuals with the lowest VAI, those who had the highest VAI were at 2.55-fold risk of diabetes (95% CI: 1.58-4.11). The largest AUC was observed for VAI, following by WC, WHtR and BMI.ConclusionsVAI is positively associated with the risk of diabetes. Compared to other indices for body fatness measurements, VAI is a better and convenience surrogate marker for visceral adipose measurement and could be used in identifying the risk of diabetes in large-scale epidemiologic studies.
Highlights
Diabetes has become a worldwide public health problem seriously threatening human health [1]
Matsuda summarized that adipose tissue is a main source of reactive oxygen species, which may contribute to the development of obesity-associated insulin resistance (IR) and cause type 2 diabetes as a consequence [7]
As compared to individuals with the lowest Visceral adiposity index (VAI), those who had the highest VAI were at 2.55-fold risk of diabetes
Summary
Diabetes has become a worldwide public health problem seriously threatening human health [1]. The results of 2007–2008 National Diabetic Epidemiological Survey showed that the prevalence of diabetes in China was 9.7%, and estimated that the number of Chinese diabetic patients is 92.4 million, Many studies have confirmed that obesity plays an important role in the development of diabetes. Matsuda summarized that adipose tissue is a main source of reactive oxygen species, which may contribute to the development of obesity-associated IR and cause type 2 diabetes as a consequence [7]. Obese people may vary in their body fat distribution and disease risk, and regional adipose tissue distribution was found as a key role in explaining the relationship between adiposity and glycometabolism. It is reported that individuals with high visceral adiposity are associated with increased risks of IR and metabolic disorders, and are more likely to suffer from diabetes [8,9]. We evaluate the efficacy of VAI in identifying diabetes risk in Chinese people, and compare the predictive ability between VAI and other body fatness indices, i.e., waist circumference (WC), body mass index (BMI) and waist- to- height ratio (WHtR)
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