Abstract
BackgroundChlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci. Diagnostic tools, including culture, serologic test and PCR-based methods, are available but prone to false negative results.Case presentationThis report included five cases of Chlamydia psittaci pneumonia. Symptoms and signs common to all 5 cases included fever, coughing, generalized muscle ache, and most notably, inflammatory infiltration of the lungs upon chest CT and X-ray. Metagenomic next-generation sequencing (mNGS) revealed the presence of Chlamydia psittaci in biopsy lung tissue in 3 cases and bronchoalveolar lavage fluid in the remaining 2 cases. Three patients responded to doxycycline plus moxifloxacin; two patients responded to moxifloxacin alone.ConclusionsmNGS could be used to diagnose Chlamydia psittaci pneumonia.
Highlights
Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci
Chlamydia psittaci can be classified into 10 genotypes, with varying preference for host species [5]
After entry via contaminated aerosols, Chlamydia psittaci spreads to the reticuloendothelial system
Summary
The application of metagenomic nextgeneration sequencing in diagnosing Chlamydia psittaci pneumonia: a report of five cases. Lei Gu1,2†, Wei Liu2†, Meng Ru3, Jing Lin, Guoqing Yu4, Jia Ye2, Zheng-an Zhu, Yuebin Liu, Jian Chen, Guoxiang Lai and Wen Wen2*
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
