Abstract
In this study, lactic acid bacteria (LAB) strains derived from human and fermented food sources were examined to identify their properties related to obesity, as well as establish their safety and stability as probiotics. LAB (Lacticaseibacillus rhamnosus MG4502, Lactobacillus gasseri MG4524, Limosilactobacillus reuteri MG5149, and Weissella cibaria MG5285) exhibited antioxidant activity through DPPH (>26.1%) and ABTS (>40.1%) radical scavenging assays and α-glucosidase inhibitory activities (>60.3%), respectively. The LAB strains promoted anti-adipogenesis by reducing lipid accumulation in 3T3-L1 cells by Oil Red O staining (>70.3%). In addition, we found that these LAB strains were resistant to simulated gastric and intestinal fluids (pH 3, 4, 7, and 8) and showed potential for health promotion, based on hemolysis, cell adhesion, antibiotic susceptibility, and enzyme production. Thus, LAB may be used as probiotic ingredients with beneficial effects.
Highlights
The World Health Organization (WHO) defines obesity and overweight as an abnormal or excessive accumulation of fat that presents a risk to the health of an individual [1]
Gut dysbiosis is linked with an increase in oxidative stress, which is known to act in a complex manner in various diseases [8]
Probiotics are defined as live microorganisms that confer health benefits to the host [9]
Summary
The World Health Organization (WHO) defines obesity and overweight as an abnormal or excessive accumulation of fat that presents a risk to the health of an individual [1]. Obesity is a significant risk factor for metabolic diseases such as type 2 diabetes (T2D), dyslipidemia, cardiovascular disease, hypertension, subclinical chronic low-grade inflammation, and cancer [2,3,4]. Many efforts have been made to reduce overweight and obesity rates and prevent related noncommunicable diseases. Gut dysbiosis is linked with an increase in oxidative stress, which is known to act in a complex manner in various diseases [8]. Probiotics are defined as live microorganisms that confer health benefits to the host [9]. LAB, in studies on anti-adipogenesis activity, showed potential effects on the treatment and prevention of diseases without adverse consequences [10]. LAB alleviate T2D without adverse side effects by regulating α-glucosidase activity [11,12]. Oxidative stress, such as hydroxyl radicals (OH) and superoxide anions (O2 − ), increased pre-adipocyte proliferation
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