Abstract
Objective Recently there are a lot of attempts to treat obesity through the energy expenditure. Especially UCP-1 and PPARδ are known to play a key role for energy dissipation through the increasing thermogenesis. Gambihwan extract is a traditional medicine made of herbs, Croton tiglium and Scorpion, containing the polyunsaturated fatty acids related to the energy expenditure. It is expected that one can reduce weight by means of the expressions of UCP-1 and PPARδ. Materials and methods We divided 24 rats into three groups and assigned eight rats to each. Rats were categorized as normal, control and experimental groups. Normal group was administered normal diet, control group was administered high-fat diet and experimental group was administered high-fat diet with Gambihwan extracts 50 mg/kg. And then the weight of body, food intake, the changes of lipids in blood stream and the expressions of protein and mRNA of UCP-1 and PPARδ on adipose tissues were measured. Results 1. The body weight of control group significantly increased compared to that of normal group from 8th week to 10th week. The body weight of experimental group decreased compared to that of control group in 10th week. 2. We observed the HDL-cholesterol level of experimental group significantly compared to that of control group. 3. The weight of visceral adipose tissue of experimental group decreased compared to that of control group. 4. Expressions of UCP-1 and PPARδ protein of experimental group significantly compared to that of control group, and the mRNA expressions of UCP-1 and PPARδ of experimental group, compared with control group, tend to decrease. Conclusion In the experimental group the triglyceride level is decreased and the HDL-cholesterol level and the expression of PPARδ and UCP-1 protein on visceral adipose tissue were significantly increased. The reduction of body weight and an increasing tendency of expressions of UCP-1 and PPARδ mRNA were shown in experimental groups. These results indicate that Gambihwan extract upregulates the expressions of UCP-1 and PPARδ in adipose tissue, which may contribute to reducing the weight of adipose tissue.
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