Abstract
The antidiabetic activity of the new composition “Thigliben” on the experimental dexamethasone diabetes mellitus model in rats
Highlights
It was found that by its effects on the carbohydrate and lipid metabolism the new composition “Thigliben” was similar to the reference drug glibenclamide administered in a higher dose
Animals of the control pathology group under conditions of the experimental insulin-independent diabetes mellitus demonstrated a significant increase in the body weight; the gain value was 2.15 times higher than in that of the intact control group
The treatment-and-prophylactic administration of “Thigliben” composition allowed controlling changes in the body weight along with administration of dexamethasone and a high carbohydrate diet, the value of body weight gain was slightly higher than that in the group of rats treated with the reference drug glibenclamide in a higher average therapeutic dose
Summary
It was found that by its effects on the carbohydrate and lipid metabolism the new composition “Thigliben” was similar to the reference drug glibenclamide administered in a higher dose. By the antioxidant activity this composition exceeded the effect of the reference drug, provided that normalization of the TBA-RS level in the liver homogenate was significant. The new composition “Thigliben” normalized all the parameters of the cerebral energy metabolism studied relative to the control pathology group and its efficiency was significantly higher than that of the reference drug glibenclamide. The results obtained suggest that the metabolic effect of “Thigliben” composition is significantly more effective than that of the reference drug glibenclamide
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