The antibacterial activity of contact lens solutions against microbial keratitis

Abstract

Background: Contact lens has a growing popularity among people with vision impairment as well as for cosmetic reasons. However, its contamination can cause microbial keratitis. This study aimed to test the effectiveness of three antimicrobial contact lens solutions against microbial keratitis and to determine the contact time and adjustments in the existing label of multipurpose solutions. Aims and Objectives: To study the antimicrobial activity of three locally available contact lens solutions against Pseudomonas aeruginosa and Staphylococcus aureus and determined their contact time. Materials and Methods: Three bottles of each contact lens solution were evaluated using a single-blind controlled experiment method. These test solutions were categorized based on their identified disinfecting ingredient. This study evaluated the antibacterial activity of three contact lens solutions against P. aeruginosa and S. aureus at different contact times of 1, 3, 6, and 12 h. Results: All samples of contact lens solutions tested showed excellent antimicrobial activity. The contact lens solution B had the highest antibacterial activity against S. aureus and P. aeruginosa with a contact time of 6 h. Conclusion: The results showed that all the contact lens solutions demonstrate antimicrobial activity even after 24 h of exposure. Contact lens solutions containing polyhexamethylene biguanid as the active agent are found to have excellent antimicrobial activity and a desirable contact time.