Abstract
Prosopis chilensis is used locally in Sudan for inflammatory conditions of joints; however, literature lacks scientific evidence for anti-inflammatory effect of this plant. To evaluate anti-inflammatory and analgesic effects of prosopis chilenses. Edema inhibition percent (EI %) and hot plate method were used to evaluate anti-inflammatory and analgesic effects of Prosopis chilenses in Wistar albino rats. Anti-inflammatory and analgesic effects of Prosopis chilenses were compared to indomethacin and acetylsalicylic acid respectively. Ethanolic extract of prosopis chilensis at a dose of 200 and 100mg/kg body weight achieved peak EI% (EI% = 96.1%) and (EI% = 94.4%) three and four hours after oral dosing respectively. The maximum EI% for indomethacin was 97.0% and was recorded after 4 hours following oral administration of the drug at a dose of 5 mg/kg body weight. Prosopis chilensis extracts at doses of 100 and 200 mg/kg body weight significantly increased the rats' response time to hot plate compared to acetylsalicylic acid at a dose rate of 100mg/kg body weight (P<0.05). The current results suggest potential anti-inflammatory and analgesic effects of prosopis chilenses. Relevance of these effects to prosopis chilenses phy-to-constituents was discussed.
Highlights
Prosopis chilensis extracts at doses of 100 and 200 mg/kg body weight significantly increased the rats’ response time to hot plate compared to acetylsalicylic acid at a dose rate of 100mg/kg body weight (P
The current results suggest potential anti-inflammatory and analgesic effects of prosopis chilenses
The peak response was recorded after 90 minutes of the oral administration of all types of treatments offered to the rats
Summary
Medicinal plants are the basis for the treatment of various diseases. [1,2,3] Alternatively, synthetic drugs are dominating the market but element of toxicity that these drugs entail, cannot be ruled out. [4,5,6] The medicinal properties of prosopis chilensis (Mesquite) are well known and utilized as medicinal plant by many tribes throughout the world. [7, 8] Algarrobo (prosopis chilensis (Mol) Stuntz) flour is used as protein and dietary fiber source in cookies and fried chips manufacture. [10] Prosopis pallida has alphaglucosidase and angiotensin converting enzyme inhibitory activities which reflect its antidiabetic and antihypertensive potential. [11] The aqueous extract of prosopis chilensis has soothing, astringent, and antiseptic properties. [12] In addition, the extract of the prosopis Africana stem is used to treat fever while barks extract is used as remedy in rheumatism and scorpion sting. [13] In Sudan, prosopis chilensis plants are abundant and sometimes used for inflammatory conditions of joints. [13] This study aims to evaluate the ant-inflammatory and analgesic properties of prosopis chilenses. Prosopis chilensis is used locally in Sudan for inflammatory conditions of joints; literature lacks scientific evidence for anti-inflammatory effect of this plant. Aims: To evaluate anti-inflammatory and analgesic effects of prosopis chilenses. Material and Methods: Edema inhibition percent (EI %) and hot plate method were used to evaluate anti-inflammatory and analgesic effects of Prosopis chilenses in Wistar albino rats. Anti-inflammatory and analgesic effects of Prosopis chilenses were compared to indomethacin and acetylsalicylic acid respectively. Results: Ethanolic extract of prosopis chilensis at a dose of 200and 100mg/kg body weight achieved peak EI% (EI% = 96.1%) and (EI% = 94.4%) three and four hours after oral dosing respectively. Conclusion: The current results suggest potential anti-inflammatory and analgesic effects of prosopis chilenses.
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