The ankle‐brachial pressure index and it's correlation with oxidative stress in Acute Myocardial Infarction

Abstract

BackgroundIn recent years significant attention has been paid in identifying markers of increased cardiovascular risk, in particular the coronary artery disease. The ankle‐brachial pressure index (ABI), an easily accessible, inexpensive bedside test can be a significant tool to assess the vascular risk in symptomatic and asymptomatic cardiovascular patients. Oxidative stress and lipid peroxidation is thought to play a crucial role in the generation of atherosclerotic lesions of Acute Myocardial Infarction (AMI).ObjectiveTo determine the association between an abnormal ankle brachial index (ABI) and oxidative stress in coronary artery disease (CAD).MethodThe study population included 160 subjects divided in two groups, 90 patients with AMI and 70 age and sex matched healthy subjects as controls. Ankle Brachial Pressure Index (ABI) was measured in all the subjects along with their LDH level. Antioxidant status of the individuals was determined by measuring the serum levels of Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD). Estimation of Malondialdehyde (MDA), a marker of lipid peroxidation was used as a surrogate marker of free radical activity.ResultA significantly low ABI (<0.9) was observed among the AMI patients as compared to healthy controls. Moreover the ABI showed negative correlation with the level of LDH amd MDA in the AMI patient. GPx and SOD were positively correlated with ABI.ConclusionABI calculation would be able to identify more patients at high risk and as such it should be considered routine investigation for cardiovascular risk prediction.Support or Funding InformationTRAVEL GRANT AND REGISTRATION GRANT FINANCIAL ASSISTANCE REQUIRED TO TRAVEL TO CHICAGO.REQUEST TO ORGANIZERS TO PROVIDE ASSISTANCE.