Abstract
The ameliorating effects of aqueous and ethanolic extracts of LiuWei Dihuang Wang (LDW W and LDW E) after single, 1-week or 2-week consecutive treatment on the cycloheximide-induced amnesia by using the passive avoidance task in rats were studied. After single treatment, LDW W and LDW E (1 and 2 g/kg) significantly prolonged the shortened step-through latency induced by CXM and their potency was equal. LDW W at 1 g/kg after 1-week consecutive treatment or at 0.1 g/kg after 2-week consecutive treatment almost completely reversed CXM-induced amnesia. LDW W at any dose alone after single, 1-week or 2-week consecutive treatment did not influence the step-through latency in the training trial in rats. Furthermore, muscarinic antagonist scopolamine, peripheral cholinergic antagonist scopolamine methylbromide, serotonin precursor 5-hydroxytryptamine and serotonin releaser p-chloroamphetamine could block the ameliorating effects of LDW W. GABA A receptor antagonist bicuculline and GABA B receptor agonist baclofen also blocked the ameliorating effects of LDW W. These results suggest that the ameliorating effects of LDW whose potency were parallel to treatment duration might be related to activating peripheral cholinergic neuronal system and modulating the central nervous system.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
