Abstract
Changes in liposome diameter in response to a pH gradient during uptake of doxorubicin were studied. After an initial increase liposomes underwent shrinkage which was dependent on lipid composition and temperature of incubation. Changes in fluorescence undergone by the drug during the active trapping process were also monitored. The observed self-quenching of doxorubicin was consistent with the kinetics of drug entrapement within the internal aqueous compartment of the vesicles except when incubation was carried out at 37°C in the presence of cholesterol.
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