Abstract
1. 1. The growth rate of brown trout increased when thyroxine was added to the tank water at or above a concentration of 3·75 μM; but declined again when the concentration was raised to 12·75 μM. 2. 2. Mitochondria isolated from trout treated with 3·75 μM thyroxine for at least 14 days showed decreased phosphorylatory efficiency and increased specific activity of oxidative enzyme systems; thiourea treatment tended to reverse these results. 3. 3. Thyroxine administered in vitro to mitochondria from untreated fish uncoupled oxidation and phosphorylation at concentration lower than than reported for mammals. 4. 4. The results are discussed with reference to recent views on thyroid action in mammals and it is suggested that the data from trout mitochondria support and confirm the mammalian work.
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