Abstract
J. Watrous and E. P. Walsh. The action of Chrysaora quinquecirrha (sea nettle) toxin in inhibiting the intestinal transport of glucose in the golden hamster. Toxicon 14, 179–183, 1976—Experiments were conducted to study the effects of Chrysaora quinquecirrha toxin on the sodium-linked transport of glucose in hamster small intestine. Everted strips of tissue were exposed to whole toxin while incubating in buffers with various glucose or sodium concentrations. In all cases, the per cent depression of glucose uptake was nearly identical, indicating non-competitive inhibition of the active transport process. It is suggested that Chrysaora nematocyst toxin alters a property of the brush border membrane, thereby increasing its permeability to Na + ions.
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