The Abuse of Neurodegeneration Disease and How CRISPR-Cas9 Could Help with The Disease

Abstract

Neurodegenerative disease has been discovered for more than a hundred years. This disease gradually damages the brain neuron activity and leads to death. There is no way to entirely heal the disease currently but scientists are still looking for some methods to slow it down and heal from it. More hope appears after the third generation of gene editing technology-CRISPR-Cas9- is discovered. This is a natural gene editing technology by CRISPR gene and Cas9 protein in the body with more precision and less cost than the previous two generations. CRISPR-Cas9 technology is based on the natural body system that detects and prevents virus RNA, and targets a precise sequence of genes to accomplish gene editing. Researchers believe that the damage of neurons by the disease could be slowed down or even stopped by knocking out the neurodegeneration related gene and knocking in desired healthy genes. Huntington disease, one of the most popular diseases in neurodegenerative disease, has been discovered relatively more. This research review focuses on the history of CRISPR-Cas9 gene editing technology and how it helps with neurodegenerative disease, especially with Huntington Disease.