Abstract
The penetration of potassium iodide and phenolsulfonphthalein from “Carbowax” vehicles through the intact skin of albino rats has been studied. A change in rate and amount of penetration caused by the addition of silica, cetyl alcohol, wool fat, petrolatum, and “Tergitol” was demonstrated. Addition of cetyl alcohol and silica markedly reduced the absorption of the dye and the potassium iodide while the addition of petrolatum and wool fat caused a small decrease. Tergitol had little influence. A study also was made on the release of antiseptics from the same vehicles using a modified F. D. A. agar cup method. Absorption of phenolsulfonphthalein from the Carbowax base through the intact human skin was demonstrated clinically.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Pharmaceutical Sciences (Scientific Edition)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
