Abstract
BackgroundPolycystic ovary syndrome (PCOS) is a disease with chronic nonspecific low-grade inflammation. The imbalance of immune cells exists in PCOS. Several studies have found that heat shock protein 70 (HSP70) may be involved in the immunological pathogenesis of PCOS, but the relationship between HSP70 and Regulatory T cell (Treg)/T helper cell 17(Th17) ratio remains unclear. This study aims to explore the correlation between HSP70 and Treg/Th17 ratio and to provide evidence for the role of HSP70 in the immunological etiology of PCOS.ResultsThere was no significant difference in age and body mass index (BMI) between the two groups. The concentrations of basal estradiol (E2), basal follicle-stimulating hormone (FSH) did not show a significant difference between the two groups. The concentrations of basal luteinizing hormone (LH) (P < 0.01), testosterone (T) (P < 0.01), glucose (P < 0.001) and insulin (P < 0.001) in PCOS patients were significantly higher than those in the control group. The protein levels of HSP70 were significantly higher in serum in the PCOS group (P < 0.001). The percentage of Treg cells was significantly lower (P < 0.01), while the percentage of the Th17 cells of the PCOS group was significantly higher than that of the control group (P < 0.05). The ratio of Treg/Th17 in the PCOS group was significantly lower (P < 0.001). The concentrations of Interleukin (IL)-6, IL-17, and IL-23 were significantly higher, while the levels of IL-10 and Transforming growth factor-β (TGF-β) were significantly lower in the PCOS group (P < 0.001). Spearman rank correlation analysis showed a strong negative correlation of serum HSP70 levels with Treg/Th17 ratio, IL-10, and TGF-β levels. In contrast, HSP70 levels were significantly positively correlated with IL-6, IL-17, IL-23, LH, insulin, and glucose levels.ConclusionThe abnormal level of HSP70 is correlated with Treg/Th17 imbalance and corresponding cytokines, which indicates that HSP70 may play an important role in PCOS immunologic pathogenesis.
Highlights
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting approximately 6–15% of women worldwide [1]
The results showed that there was no significant difference in age and body mass index (BMI) between the two groups
heat shock protein 70 (HSP70) levels were significantly positively correlated with interleukin 6 (IL-6) (P < 0.001), interleukin 17 (IL-17) (P < 0.001), interleukin 23 (IL-23) (P < 0.01), luteinizing hormone (LH)(P < 0.01), insulin (P < 0.001), and glucose (P < 0.01) levels
Summary
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting approximately 6–15% of women worldwide [1]. HSPs. Yang et al Journal of Ovarian Research (2021) 14:155 participate in the regulation of cell function and play an important role in the maintenance of protein homeostasis [6]. Yang et al Journal of Ovarian Research (2021) 14:155 participate in the regulation of cell function and play an important role in the maintenance of protein homeostasis [6] Among these proteins, heat shock protein 70 (HSP70) is the most conserved protein, which has a variety of biological functions including molecular chaperone, regulation of immune response, anti-apoptosis, and improvement of cell tolerance to stressors [7]. Several studies have found that heat shock protein 70 (HSP70) may be involved in the immunological pathogenesis of PCOS, but the relationship between HSP70 and Regulatory T cell (Treg)/T helper cell 17(Th17) ratio remains unclear. This study aims to explore the correlation between HSP70 and Treg/Th17 ratio and to provide evidence for the role of HSP70 in the immunological etiology of PCOS
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