The ability of the instrumented tandem walking tests to discriminate fully ambulatory people with MS from healthy adults

Abstract

BackgroundPeople with multiple sclerosis (PwMS) experience walking and balance deficits at the initial phases of the disease, even when classified as only minimally disabled. Complex balance tasks, such as tandem walking, are probably more sensitive in detecting mild balance difficulties compared to the standard traditional tests in this population. Research questionThe aim was to investigate different types of 3-meter tandem walking tests in fully ambulatory PwMS. MethodsThis observational case-control study included 50 participants; 25 PwMS, 17 women and 8 men, aged 35.2 (S.D = 8.6) and 25 healthy subjects, 18 women and 7 men, aged 34.3 (S.D = 6.1). The 3-meter tandem walk tests were performed during a single session. Each subject completed a sequence of 3 consecutive tests under 3 different task conditions: normal tandem walking, backward tandem walking and cognitive tandem walking. Tandem walking tests were evaluated via three small, lightweight axial wearable accelerometers (APDM, Oregon, USA). ResultsThe mean EDSS for the MS group was 1.6 (S.D = 0.6) indicating minimal disability. PwMS walked slower and at a slower pace, with a prolonged double support and decreased swing phase compared to healthy subjects in normal and backward conditions. In contrast, during the cognitive task, non-significant differences were found in gait measures between the PwMS and the healthy controls. Significant differences were found between task conditions for all participants. All reduced their walking speed and walked at a slower pace in both the cognitive and backward conditions compared to the normal tandem walk condition. However, non-significant scores were found for the condition X group factor. SignificanceThe study provides new insights into the 3-meter tandem walk test. Findings should improve evaluation and training of dynamic balance in fully ambulatory PwMS.