Abstract
Background: The transforming growth factor-β1 (TGF-β1) gene -509C/T polymorphism has been suggested to be associated with increased coronary artery disease (CAD) risk. However, the individual studies results are still inconsistent.Objective and methods: To investigate the relationship between TGF-β1 gene -509C/T polymorphism and CAD, a meta-analysis involving 11,701 participants from 8 individual studies was conducted. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals were evaluated by using random or fixed effect models.Results: A significant association between TGF-β1 gene -509C/T polymorphism and CAD was detected in the total population under allelic (OR: 1.130, 95% CI: 1.060–1.200, P = 0.0001), recessive (OR: 1.390, 95% CI: 1.100–1.750, P = 0.006), dominant (OR: 0.857, 95% CI: 0.785–0.935, P = 2.507 × 10−4), homozygous (OR: 1.258, 95% CI: 1.098–1.442, P = 0.001), heterozygous (OR: 1.147, 95% CI: 1.046–1.257, P = 0.003), and additive genetic models (OR: 1.131, 95% CI: 1.063–1.204, P = 5.442 × 10−5). In the subgroup analysis, there was a significant association between them in Chinese population under all of the genetic models (P < 0.05), except under the heterozygous genetic model (P > 0.05). In the Caucasian subgroup, a significant association between them was also detected under all of the genetic models (P < 0.05), except under the recessive genetic model (P > 0.05).Conclusions: TGF-β1 gene -509C/T polymorphism was significantly associated with increased CAD risk. The people with T allele of TGF-β1 gene -509C/T polymorphism might be predisposed to CAD.
Highlights
The coronary artery disease (CAD) morbidity rose markedly which presented a rejumvanation trend (Zou et al, 2013)
A significant association between transforming growth factor-β1 (TGF-β1) gene -509C/T polymorphism and CAD was detected in the total population under allelic (OR: 1.130, 95% confidence intervals (CIs): 1.060–1.200, P = 0.0001), recessive (OR: 1.390, 95% CI: 1.100–1.750, P = 0.006), dominant (OR: 0.857, 95% CI: 0.785–0.935, P = 2.507 × 10−4), homozygous (OR: 1.258, 95% CI: 1.098–1.442, P = 0.001), heterozygous (OR: 1.147, 95% CI: 1.046–1.257, P = 0.003), and additive genetic models (OR: 1.131, 95% CI: 1.063–1.204, P = 5.442 × 10−5)
TGF-β1 gene -509C/T polymorphism was significantly associated with increased CAD risk
Summary
The coronary artery disease (CAD) morbidity rose markedly which presented a rejumvanation trend (Zou et al, 2013). According to the mortality and disability rate, CAD is the most important disease in the United States of America (USA) and other industrialized countries. In the nearly one million patients who died of the cardiovascular disease in USA every year, CAD accounted for 50%. About 1.5 million USA patients were attacked by acute myocardial infarction which was TGF-β1 Gene -509C/T Polymorphism and CAD almost caused by coronary atherosclerosis (Yang et al, 2006). CAD is the myocardial ischemia or necrosis disease caused by the artery lumen stenosis due to the coronary atherosclerosis. The CAD pathogenesis might be the combined actions result by heredity and environmental factors. The single nucleotide polymorphism is the important genetic factor which influences the CAD susceptibility. The transforming growth factor-β1 (TGF-β1) gene -509C/T polymorphism has been suggested to be associated with increased coronary artery disease (CAD) risk.
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