Abstract
目的 建立小鼠同种异体角膜移植模型,观察静脉注入抗原递呈细胞对术后免疫排斥的影响.方法 建立BALB/c→C57BL/6小鼠角膜移植模型.随机分2组,静脉注入耐受型或普通抗原递呈细胞.根据植片混浊评分,判断植片排斥情况.随机取两组小鼠脾脏检测CD4+ NKT百分比和IL-10质量分数.结果 与对照组相比,实验组移植排斥出现晚(19 d±1.6 d,P＝0.009).术后脾脏CD4+NKT百分比、IL-10质量分数相对恒定.结论 小鼠角膜移植术后耐受型抗原递呈细胞静脉注射可延长植片存活时间。
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