Abstract
A series of tetrahydro-β-carboline-naphthalimide hybrids has been designed and synthesized via an amide coupling reaction. The obtained hybrids were evaluated for their growth inhibitory potential against MCF7 and MDA-MB-231 breast cancer cell lines using MTT assay. Three of the promising hybrids with IC50s < 43 μM were further scrutinized for their interactions with selected target i.e. Estrogen Receptor, ERα. Thus, the designed template showed a decent growth inhibitory potential on Breast Cancer (BC) cells with high safety profile and hence, the present manuscript reveals the success rate of hybridization technique in clubbing two individual anti-cancer cores i.e. THβC and naphthalimide.
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